FIELD: medicine. SUBSTANCE: the method describes formula 1-compounds and their N-alkylated derivatives, where substitutes have got the values mentioned in the description. It is, also, described how to obtain pharmaceutical composition able to inhibit thrombin and which includes therapeutically efficient amount of formula I 
compound and pharmaceutically acceptable carriers. The methods to inhibit thrombin and trypsin are suggested which imply the contact of formula I-compound with thrombin- or trypsin-containing medium, correspondingly. EFFECT: higher efficiency. 35 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| MACROHETEROCYCLIC COMPOUNDS | 2001 |
|
RU2275373C2 |
| CARBOXAMIDE DERIVATIVES OF PYRROLIDINE OR PIPERIDINE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION OF PLATELET AGGREGATION | 1997 |
|
RU2194038C2 |
| 4-PHENYLPIPERAZINE AND 4-PHENYLPIPERIDINE OXIDES, COMPOSITION BASED ON THEREOF AND A METHOD OF INHIBITION OF DOPHAMINE-2 RECEPTORS | 1994 |
|
RU2123001C1 |
| BENZOXAZINE OR PYRIDOOXAZINE COMPOUNDS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS SHOWING ANTIBACTERIAL ACTIVITY, METHODS OF TREATMENT OF BACTERIAL INFECTIONS | 1996 |
|
RU2191179C2 |
| ANTIBACTERIAL HETEROBICYCLIC SUBSTITUTED PHENYLOXAZOLIDINONES | 2000 |
|
RU2278117C2 |
| NIPECOTINIC ACID DERIVATIVES AS AGENTS THAT PREVENT BLOOD CLOT FORMATION | 1995 |
|
RU2135470C1 |
| PSEUDOFRUCTOPYRANOSE SULFAMATES AND PHARMACEUTICAL COMPOSITION BASED ON SAID | 1994 |
|
RU2139875C1 |
| PEPTIDE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF THROMBIN INHIBITION IN MAMMAL | 1995 |
|
RU2148585C1 |
| PHOSPHONIC ACID COMPOUNDS AS SERINE PROTEINASE INHIBITORS | 2002 |
|
RU2311421C2 |
| SYMMETRIC AND ASYMMETRIC DERIVATIVES OF DIPHENYLUREA (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF RAF KINASE- MEDIATED TUMOR CELLS PROLIFERATION | 1998 |
|
RU2247109C9 |
