1,5,6-SUBSTITUTED 2-OXO-3-CYANO-1,6A-DIAZATETRAHYDROFLUORANTHENES Russian patent published in 2010 - IPC C07D471/16 C07D498/16 A61K31/4985 A61P31/18 

Abstract RU 2389730 C2

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula , to their salts, where R1 and R2 each independently is hydrogen or C1-10alkyl which can be optionally substituted with substitutes selected from a group comprising a hydroxyl group, NR4R5, pyrrolidinyl, piperidinyl, morpholinyl; R3 is a radical of formula , where n equals 1; R3a is nitro; X is -NR7 - or -O-; R4 and R5 each independently is C1-6alkyl; R7 is hydrogen, C1-6alkyl, optionally substituted with pyrrolidinyl. The invention also pertains to use of the compounds, to a pharmaceutical composition, to a method of preparing the pharmaceutical composition, as well as to a method of obtaining the chemical compound in any of paragraphs 1-3.

EFFECT: obtaining new biologically active compounds with antiviral activity.

7 cl, 4 ex, 2 tbl

Similar patents RU2389730C2

Title Year Author Number
5-SUBSTITUTED 1-PHENYL-1,5-DIHYDROPIRIDO[3,2-b]INDOLE-2-ONES AND ANALOGUES AS ANTI-VIRUS PREPARATIONS 2005
  • Kestelejn Bart Rudol'F Romani
  • Kanar Maksim Fransis Zhan-Mari Gilejn
  • Van De Frejken Vim
  • Rabuasson P'Er Zhan-Mari Bernar
  • Sjurlero Dominik Lui Nestor Gilehjn
  • Vigerink Pit Tom Bert Pol'
RU2362776C2
6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDROPYRIDO (3,2-b) INDOLE-2-ONES EFFECTIVE AS ANTIINFECTIOUS PHARMACEUTICAL AGENTS 2005
  • Kestelejn Bart Rudol'F Romani
  • Vendevill' Sandrin Mari Ehlen
  • Kindermans Natali Marija Frantsiska
  • Sjurlero Dominik Lui Nestor Gilehjn
  • Rabuasson P'Er Zhan-Mari Bernar
  • Vigerink Pit Tom Bert Pol'
  • Peters Annik Ann
RU2377243C2
HIV-INHIBITING 5-AMIDO-SUBSTITUTED PYRIMIDINES 2007
  • Gijemon Zherom Ehmil' Zhorzh
  • Pogam Mikaehl'
  • Dele Bruno Fransua Mari
RU2480464C2
HIV-INHIBITING BICYCLIC PYRIMIDIN DERIVATIVES 2005
  • Gijemon Zherom Ehmil' Zhorzh
  • Pogam Mikaehl'
  • Dele Bruno Fransua Mari
  • Kheres Jan
  • Levi Paulus Joannes
  • Zhanssen Pol' Adrian Jan
RU2403254C2
HIV-INHIBITING 5-CARBO- OR HETEROCYCLIC SUBSTITUTED PYRIMIDINES 2005
  • Gijemon Zherom Ehmil' Zhorzh
  • Kheres Jan
  • Levi Paulus Joannes
RU2403244C2
HIV INHIBITING 5-HETEROCYCLYL PYRIMIDINES 2005
  • Gijemon Zherom Ehmil' Zhorzh
  • Kheres Jan
  • Levi Paulus Joannes
RU2405778C2
DERIVATIVES OF 5- OR 6-SUBSTITUTED BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION 2004
  • Bonfanti Zhan-Fransua
  • Andris Kunrad Jozef Lodevejk
  • Fortehn Zherom Mishel' Klod
  • Mjuller Filipp
  • Duble Frederik Mark Moris
  • Mejer Kristof
  • Villebrords Rudi Ehdmond
  • Zhever Tom Valerius Zhozefa
  • Timmerman Filip Marija Marta Bern
RU2369606C2
MACROCYCLIC PHENYLCARBAMATES INHIBITING HCV 2008
  • Rabuasson P'Er Zhan-Mari Bernar
  • Antonov Dmitrij
  • Ajesa Alvares Susana
  • Bel'Frage Anna Karin Gertrud Linnea
  • Jensson Karl Ehrik Daniehl'
  • Mak Govan Dehvid Krejg
  • Nil'Sson Karl Magnus
  • Rosenkvist Osa Annika Kristina
  • Samuehl'Sson Bengt Bertil'
RU2490261C2
2-SUBSTITUTED BENZIMIDAZOLES 2006
  • Bonfanti Zhan-Fransua
  • Mjuller Filipp
  • Fortehn Zherom Mishel' Klod
  • Duble Frederik Mark Moris
RU2441866C2
HIV-INHIBITING 5-(HYDROXYMETHYLENE- AND AMINOMETHYLENE)SUBSTITUTED PYRIMIDINES 2007
  • Gijemon Zherom Ehmil' Zhorzh
  • Mordan Selin Izabell'
  • Shmitt Benua Antuan
RU2452737C2

RU 2 389 730 C2

Authors

Kestelejn Bart Rudol'F Romani

Rabuasson P'Er Zhan-Mari

Van De Frejken Vim

Kanar Maksim Fransis Zhan-Mari Gilehjn

Dates

2010-05-20Published

2006-01-10Filed