FIELD: medicine.
SUBSTANCE: strain A/IIV-Moscow/01/09(HlNl)sw1 of influenza virus is recovered during pandemia in 2009 in Moscow from a patient. The new hybrid strain is produced by fusion of mice myeloma cells (Sp2/0) and spleen cells of a Balb/C mouse immunised with a purified and inactivated preparation of the pandemic influenza strain A/IIV-Moscow/01/09(HlNl)sw1. The hybrid cell strain of Mus. Musculus 1E7 is deposited in the Collection of Cell Cultures of Federal State Institution Ivanovsky Research Institution of Virology of the Ministry of Healthcare and Social Development of the Russian Federation, No. 8/2/4. A copyrighted name of the hybridoma cell line is 1E7. Using the hybridoma enables producing specific monoclonal antibodies to haemagglutinin protein of the pandemic influenza virus A(HlNl)sw1 which may be applicable for studying of an antigene structure of haemagglutinin, for differential diagnosing of the pandemic influenza A viruses.
EFFECT: high virus-neutralising activity of the MCA enables producing humanised antibodies for specific prevention and treatment.
1 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| REASSORTANT ReM8-VACCINE STRAIN OF SUPTYPE H1N1 INFLUENZA A VIRUS | 2011 |
|
RU2457245C1 |
| STRAIN OF HYBRID CULTIVATED MURINE CELLS Mus Musculus-6F3 PRODUCING MONOCLONAL ANTIBODY NONTOLERANT TO HEMAGGLUTININ PROTEIN OF HIGH-PATHOGEN STRAIN virus A/duck/Novosibirsk/56/05 H5N1 | 2008 |
|
RU2385929C1 |
| STRAIN OF HYBRID CULTIVATED MURINE CELLS Mus Musculus - 4F11 PRODUCING MONOCLONAL ANTIBODY RESPONDER WITH HEMAGGLUTININ PROTEIN OF HIGH-PATHOGEN STRAIN virus A/duck/Novosibirsk/56/05 H5N1 | 2008 |
|
RU2384617C1 |
| STRAIN OF HYBRID ANIMAL CELLS Mus MUSCULUS 1F1 - PRODUCER OF A MONOCLONAL ANTIBODY AGAINST THE NUCLEOCAPSID PROTEIN N OF THE SARS-CoV-2 VIRUS | 2021 |
|
RU2769817C1 |
| STRAIN OF HYBRID ANIMAL CELLS MUS MUSCULUS 2E1B5 - PRODUCER OF A MONOCLONAL ANTIBODY AGAINST THE RECEPROT-BINDING DOMAIN OF PROTEIN S OF THE SARS-CoV-2 VIRUS | 2021 |
|
RU2771288C1 |
| STRAIN OF FLU VIRUS A/IIV-Anadyr/177-ma/2009 (H1N1) pdm09, ADAPTED TO TISSUES OF LIGHT LABORATORY RODENTS | 2012 |
|
RU2487936C1 |
| STRAIN OF INFLUENZA A VIRUS/ IIV-Moscow/01/2009 (HLNL)swl FOR ELABORATION OF MEANS AND METHODS OF BIOLOGICAL PROTECTION | 2009 |
|
RU2412244C1 |
| STRAIN OF HYBRID CULTIVATED CELLS OF MUS MUSCULUS FOR PRODUCING MONOCLONAL ANTIBODIES TO HEMAGGLUTININ OF INFLUENCA VIRUS | 0 |
|
SU1446156A1 |
| INHIBITOR OF INFLUENZA A VIRUS REPRODUCTION BASED ON EXTRACT OF BASIDIAL FUNGUS Laetiporus sulphureus | 2011 |
|
RU2475530C2 |
| REASSORTANT RN A9-SWINE A(H7N1) INFLUENZA VIRUS STRAIN FOR NEURAMINIDASE ANTIBODY ASSAY IN INFLUENZA INFECTION AND VACCINATION | 2010 |
|
RU2428476C1 |
