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2 771 288

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IPC

C12N5/16(2006-01-01)

A61K39/395(2006-01-01)

A61K39/42(2006-01-01)

(21) (22)

Application

2021102351, 2021-02-02

(24)

Start date

2021-02-02

(22)

Actual filing date

2021-02-02

(45)

Published

2022-04-29

(72)

Inventor

Cherepushkin Stanislav AndreevichGrebennikova Tatyana VladimirovnaTsibezov Valerij VladimirovichLarichev Viktor FilippovichShcheblyakov Dmitrij ViktorovichEsmagambetov Ilyas BulatovichFavorskaya Irina AlekseevnaDerkaev Artem AlekseevichGintsburg Aleksandr Leonidovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Issledovatelskij Tsentr Epidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhraneniya Rossijskoj Federatsii

STRAIN OF HYBRID ANIMAL CELLS MUS MUSCULUS 2E1B5 - PRODUCER OF A MONOCLONAL ANTIBODY AGAINST THE RECEPROT-BINDING DOMAIN OF PROTEIN S OF THE SARS-CoV-2 VIRUS Russian patent published in 2022 - IPC C12N5/16 A61K39/395 A61K39/42

Abstract RU 2771288 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular, to a strain of hybrid cultured animal cells Mus musculus 2E1B5. Hybrid clone of 2E1B5 cells was produced by fusion of mouse myeloma cells of the Sp2/0-Ag-14 line with splenocytes of mice of the Balb/c line, immunised intramuscularly with the recombinant receptor-biniding domain of protein S of the SARS-CoV-2 virus. Hybridoma 2E1B5 synthesises an IgG1-class monoclonal antibody specifically interacting with the recombinant receptor-binding domain of protein S of the SARS-CoV-2 virus, full-length S protein of the SARS-CoV-2 virus, and inactivated SARS-CoV-2 virus. The antibody exhibits virus-neutralising activity and is capable of neutralising the SARS-CoV-2 virus in vitro. The resulting antibody can be used in diagnostic studies in order to detect an antigen and specific antiviral antibodies and to create medicinal products against the SARS-CoV-2 virus.

EFFECT: invention expands the range of means for producing monoclonal antibodies against protein S of the SARS-CoV-2 virus.

1 cl, 1 dwg, 1 tbl, 5 ex

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RU 2 771 288 C1

Authors

Cherepushkin Stanislav Andreevich

Grebennikova Tatyana Vladimirovna

Tsibezov Valerij Vladimirovich

Larichev Viktor Filippovich

Shcheblyakov Dmitrij Viktorovich

Esmagambetov Ilyas Bulatovich

Favorskaya Irina Alekseevna

Derkaev Artem Alekseevich

Gintsburg Aleksandr Leonidovich

Dates

2022-04-29—Published

2021-02-02—Filed