FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to a method for producing a peptide with modified lysine side chain. The invention discloses a method for producing exendin-4 analogue modified with lipophilic substituent by amino acid lysine residue using solid-phase peptide synthesis.
EFFECT: described method for producing the modified peptide using certain sequence of stages allows for significant reduction in amount of unwanted side products and increase in target product yield.
13 cl, 14 tbl, 8 ex
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