FIELD: medicine.
SUBSTANCE: there are offered: a pharmaceutical product for treating a respiratory disease containing a combination of a first active ingredient specified in a muscarine antagonist and a second active ingredient, a β2-adrenoreceptor agonist wherein each active ingredient is prepared in the form of a preparation for inhalations, a respective kit, a pharmaceutical composition. What is shown is intensifying inhibition of the declared combination of metacholine induced tracheal ring tonus in vitro vs. separate introduction of the active ingredients, including enhancing bronchoprotection (bronchostenosis inhibition) in vivo.
EFFECT: said product is applicable for preparing a drug for treating respiratory diseases, such as chronic obstructive pulmonary disease.
12 cl, 9 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NAPADISYLATE SALT OF MUSCARINIC M3 RECEPTOR ANTAGONIST | 2008 |
|
RU2459810C2 |
| AZOLE AND THIAZOLE DERIVATIVES AND USE THEREOF | 2006 |
|
RU2436779C2 |
| DERIVANTS OF BICYCLO[2, 2, 1] HEPT-7-YLAMINE AND THEIR APPLICATIONS | 2006 |
|
RU2442771C2 |
| BIPHENYL DERIVATIVES | 2004 |
|
RU2330841C2 |
| QUINUCLIDINE DERIVATIVES OF (HETERO) ARYLCYCLOHEPTANE CARBOXYLIC ACIDS AS MUSCARINE RECEPTOR ANTAGONISTS | 2007 |
|
RU2456286C2 |
| CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | 2017 |
|
RU2722720C1 |
| DIAMIDE COMPOUNDS HAVING ACTIVITY OF MUSCARINIC RECEPTOR ANTAGONIST AND ACTIVITY OF β ADRENERGIC RECEPTOR AGONIST | 2010 |
|
RU2676686C2 |
| DIAMIDE COMPOUNDS POSSESSING MUSCARINIC ANTAGONIST ACTIVITY AND B2 ADRENERGIC RECEPTOR B2 AGONIST ACTIVITY | 2010 |
|
RU2543716C2 |
| DERIVATIVES OF BENZIMIDAZOLE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2002 |
|
RU2265018C2 |
| NOCICEPTIN ANALOGUES | 2002 |
|
RU2426730C2 |
