METHOD FOR DETERMINING EARLY PREDICTORS OF ONSET OF DIFFERENTIATION SYNDROME IN TREATING PATIENTS SUFFERING ACUTE PROMYELOCYTE LEUKEMIA Russian patent published in 2012 - IPC G01N33/49 G01N33/574 

FIELD: medicine.

SUBSTANCE: method for determining early predictors of the onset of differentiation syndrome (DS) in treating the patients suffering acute promyelocyte leukemia involves measuring body temperature, counting leukocytes, promyelocytes in peripheral blood and thrombocytes, evaluating a hemoglobin level, an activated partial thromboplastin time (APTT) index anf a prothrombin index (PTI), the concentrations of fibrinogen, urea and creatinine; if observing febrile temperature, decreased thrombocyte count less than 20*10⁹/l (deep thrombocytopenia), prolonged APTT index with respect to the norm before transretinoic acid (ATRA) therapy, decreased hemoglobin to 73 g/l if prescribed after developing DS, persistent hypofibrinogenemia and deep thrombocytopenia combined with increasing ures and creatinine in progression as compared with the reference values regardless of peripheral blood leukocyte and promyelocyte count, possibility of developing differentiation syndrome may likely stated.

EFFECT: determining early predictors of the onset of differentiation syndrome in treating the patients with acute promyelocyte leukemia per-protocol.

2 ex, 2 tbl