METHOD OF DETERMINING FACTORS OF PREDICTION OF SEVERE HEMORRHAGIC COMPLICATIONS IN PATIENTS WITH ACUTE PROMYELOCYTIC LEUKEMIA IN DIAGNOSTICS Russian patent published in 2010 - IPC G01N33/49 G01N33/574 

FIELD: medicine.

SUBSTANCE: determined are quantity of leukocytes, platelets, % of promyelocytes, APTT and prothrombin indices, fibrinogen concentration, AFMC in ethanol test, products of degradation of fibrin of D-demers and Amin elecrocoagulogram. In case of leukocytosis higher than 10×109/l, reduction of platelet number lower than 15×109/l, increase of promyelocytes higher than 50%, elongation of APTT index higher than 1.3±0.05, reduction of prothrombin index lower than 77.2±1.9%, fibrinogen concentration lower than 1.5+0.1 g/l, increase of D-dimers higher than 1000 ng/ml, Amin higher than 2.5±0.1, severe hemorrhagic complications of III and IV degree of severity are predicted with high degree of probability.

EFFECT: ensured is prediction of severe hemorrhagic complications in patients with acute promyelocytic leukemia in disease diagnostics.

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