IMMUNOGENIC SUBSTANCES CONTAINING ADJUVANT OF POLYINOSINE ACID AND POLYCYTIDYLIC ACID Russian patent published in 2012 - IPC A61K39/39 A61K31/713 A61K33/06 A61K9/22 C07H21/02 A61P37/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to a composition of a polynucleotide adjuvant (PICKCa) and methods for using it for immune response manifestation. The polynucleotide adjuvant contains polyriboinosine-polycytidylic acid (PIC) wherein the PIC molecules are heterogenous by molecular weight and have molecular weight 66000 to 1200000 Dalton, at least one antibiotic and one positive ion. The invention also refers to an immunogenic composition containing the polynucleotide adjuvant together with the other immunogenic compositions, such as an antigen specified in viral, bacterial, fungal, parasitic and/or cancer antigens; as well as to methods for using such adjuvant compositions for the generation of immune response, immune response of mucosa on the antigenic compound.

EFFECT: group of inventions provides development of immune response specific for the disease in the host body.

22 cl, 38 dwg, 28 tbl, 7 ex