METHOD OF DIAGNOSING EARLY MANIFESTATIONS OF CHRONIC MERCURY INTOXICATION Russian patent published in 2012 - IPC A61B5/476 A61B5/484 A61B5/53 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurology, immunology and occupational pathology. Rheoencephalography with hypercapnic test are performed, visual evoked potentials (VEP), encephalography (EEG) are registered, level of antibodies to protein S100, level of immunoglobulin G in blood serum are determined. Canonical value is calculated by formula: Cv=3.18-0.38×a₁-1.61×a₂-0.71×a₃+0.93×a₄+1.19×a₅-0.81×a₆, where Cv is canonical value; -0.38; -1.61; -0.71; 0.93; 1.19; -0.81 are discriminant coefficients; 3.18 is constant; a₁ is intensity of blood supply in frontomastoid pool during hypercapnic test in ohm; a₂ is amplitude of peak N1 of VEP in right occipital lead in mcV; a₃ is level of antibodies to protein S100 in conv. units; a₄ is level of immunoglobulin G in g/l; a₅ is presence or absence of nidus of pathological activity on EEG: 0 - no, 1 - present; a₆ is degree of expression of diffuse changes by EEG; 0 - no, 1 - mild, 2 - moderate, 3 - expressed, 4 - severe. If Cv is lower than the constant, early manifestations of chronic mercury intoxication are diagnosed, if Cv is higher or equals the constant, chronic mercury intoxication of the first.

EFFECT: method extends arsenal of means for diagnostics of early manifestations of chronic mercury intoxication.

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