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2 463 041

(13)

(51)

IPC

A61K31/15(2006-01-01)

C07J63/00(2006-01-01)

C07J53/00(2006-01-01)

(21) (22)

Application

2011118847/15, 2011-05-10

(24)

Start date

2011-05-10

(22)

Actual filing date

2011-05-10

(45)

Published

2012-10-10

(72)

Inventor

Mel'Nikova Nina BorisovnaUshkova Tat'Jana MikhajlovnaKislitsin Aleksej NikolaevichKlabukova Irina Nikolaevna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Meditsinskaja Akademija" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Vpo Nizhgma Minzdravsotsrazvitija Rossii)

METHOD OF OBTAINING BETULINIC ACID Russian patent published in 2012 - IPC A61K31/15 C07J63/00 C07J53/00

Abstract RU 2463041 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry, in particular to method of obtaining betulinic acid. Method of obtaining betulinic acid, including betulin dispersing in donor coordinating solution, oxidation of betulin by chrome (IV) compound in presence of aluminium sulfate under specified conditions, purification of obtained betulonic acid and its reduction by sodium borohydride in isopropyl alcohol to betulinic acid.

EFFECT: method makes it possible to increase target product output.

5 cl, 1 tbl, 4 ex

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RU 2 463 041 C1

Authors

Mel'Nikova Nina Borisovna

Ushkova Tat'Jana Mikhajlovna

Kislitsin Aleksej Nikolaevich

Klabukova Irina Nikolaevna

Dates

2012-10-10—Published

2011-05-10—Filed