STABLE CRYSTALLINE CHLORIDE MODIFICATIONS DOTAP Russian patent published in 2012 - IPC C07C219/08 A61K9/127 A61K47/18 

Abstract RU 2463291 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to enantiomerically pure (2S)- or (2R)-N,N,N-trimethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanamide chloride (DOTAP chloride) which possess the transfection properties and can find application in medicine and pharmaceutics for intracellular transportation of pharmaceutically active compounds. The invention also refers to a pharmaceutical composition and the use of enantiomerically pure (2S)- or (2R)-DOTAP chloride as an ingredient for preparing drugs.

EFFECT: preparing the compounds which possess the transfection properties and can find application in medicine and pharmaceutics for intracellular transportation of pharmaceutically active compounds.

7 cl, 2 tbl, 6 dwg, 6 ex

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RU 2 463 291 C2

Authors

Placher Mikhaehl'

Khedinger Al'Fred

Dates

2012-10-10Published

2005-11-07Filed