METHOD OF NEBIVOLOL RACEMATE OBTAINMENT Russian patent published in 2010 - IPC C07D311/58 C07D413/14 C07D407/06 C07D407/12 

Abstract RU 2392277 C2

FIELD: chemistry.

SUBSTANCE: invention refers to novel method of obtaining [2S*[R*[R*[R*]]]] and [2R*[S*[S*[S*]]]]-(±)α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyrane-2-methanol] racemate of the formula (I) (nebivolol) and its pharmaceutically acceptable salts , involving stages indicated in the claim, and to intermediate compounds and methods of obtainment thereof.

EFFECT: improved method.

106 cl, 12 tbl, 20 ex

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Authors

Bader Tomas

Shtutts Al'Fred

Khofmajer Kharal'D

Bikhzel' Khans-Ul'Rikh

Dates

2010-06-20Published

2006-12-28Filed