PHARMACEUTICALLY ACCEPTABLE SALT (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY) PHENYL] AMINO] -3-CYANO-7-ETHOXY-6-QUINOLYL] -3-[(2R)- 1- METHYLPYRROLIDIN-2-YL] PROP-2-ENAMIDE, METHOD FOR PRODUCTION AND USE THEREOF IN TREATING CANCER Russian patent published in 2016 - IPC C07D401/14 A61K31/4709 A61P35/00 

Abstract RU 2583056 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a pharmaceutically acceptable salt of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide (formula (I)), where n equals 1, 2 or 3; and M is a molecule of acid, where said salt is selected from group consisting of hydrochloride, para-toluene sulphonate, methanesulphonate, maleate, succinate and L-malate. Invention also relates to method of producing salt of formula (I), pharmaceutical composition based on salt compound of formula (I) and use of salt compound of formula (I).

EFFECT: novel salt of compound of formula (I) effective in treating cancer.

10 cl, 7 tbl, 13 ex

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RU 2 583 056 C2

Authors

Li Sin

Van Bin

Dates

2016-05-10Published

2012-02-10Filed