Show metadata Hide metadata

(19)

(11)

2 463 963

(13)

(51)

IPC

A61B10/02(2006-01-01)

G01N33/52(2006-01-01)

G01N33/483(2006-01-01)

(21) (22)

Application

2011130947/14, 2011-07-26

(24)

Start date

2011-07-26

(22)

Actual filing date

2011-07-26

(45)

Published

2012-10-20

(72)

Inventor

Shvartsburd Polina MikhajlovnaAslanidi Konstantin Borisovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Teoreticheskoj I Ehksperimental'Noj Biofiziki Ran

METHOD OF DIAGNOSING CANCER AND POTENTIAL RESISTANCE OF MALIGNANT CELLS TO HYPOXIA Russian patent published in 2012 - IPC A61B10/02 G01N33/52 G01N33/483

Abstract RU 2463963 C1

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncology. To diagnose cancer and potential resistance of malignant cells to hypoxia, prepared is cell imprint or suspension of cells, for which conditions of hypoxia are created and spectro-flowmetric analysis of said cells in dynamics of development of process of photodestruction of NAD(P)H fluorescence is performed. Conclusion about presence of tumour cells and their potential resistance to hypoxia is made by increase of NAD(P)H fluorescence intensity in conditions of darkness. Conditions of hypoxia are created by placement of cell suspension or cell imprint between two glasses for cytologic analysis. Spectro-flowmetric analysis is carried out in the range 440-470 nm, with length of excitation wave 365-370 nm.

EFFECT: method makes it possible to diagnose cancer and potential resistance of malignant cells to hypoxia.

3 cl, 6 dwg, 1 ex

Similar patents RU2463963C1

Title	Year	Author	Number
RAPID METHOD FOR DETERMINING RISK OF CELL MALIGNANCY	2012	Shvartsburd Polina Mikhajlovna	RU2508542C1
METHOD FOR DIFFERENTIAL AND EARLY DIAGNOSIS OF DISEASES OF ENT ORGANS OF INFLAMMATORY AND TUMOR AETIOLOGY USING RAMAN-FLUORESCENCE SPECTROMETRY	2018	Timurzieva Alina Borisovna Kukushkin Vladimir Igorevich Artemev Dmitrij Nikolaevich	RU2726062C2
METHOD FOR OPTIMIZING LYMPH NODE DISSECTION IN PRIMARY RESECTABLE BREAST CANCER	2017	Moshurov Ivan Petrovich Azarov Grigorij Aleksandrovich Vasilev Mikhail Borisovich Asnina Nataliya Georgievna Ismagilov Artur Khalitovich	RU2691568C1
METHOD OF DETERMINATION OF RADIATION SENSITIVITY OF TUMOUR OF MOUTH MUCOSA	2008	Poljakov Pavel Jur'Evich Bychenkov Oleg Aleksandrovich Rogatkin Dmitrij Alekseevich Gurevich Larisa Evseevna	RU2387472C1
METHOD OF FLUORESCENT DIAGNOSTICS OF BASAL CELL SKIN CANCER	2008	Pobilat Anna Evgen'Evna Prokhorenkov Viktor Ivanovich Arutjunjan Gamlet Armenakovich Karacheva Julija Viktorovna	RU2387376C1
INTRAOPERATIVE DIAGNOSTIC TECHNIQUE FOR THYROID CARCINOMA	2013	Astakhova Tat'Jana Mikhajlovna Sharova Natal'Ja Petrovna Sumedi Il'Ja Ramonovich Plekhanova Anna Sergeevna Rodoman Grigorij Vladimirovich Ljupina Julija Vjacheslavovna Karpova Jaroslava Dmitrievna Gorelova Vera Sergeevna Bogomjagkova Julija Vadimovna	RU2521239C1
METHOD OF COMBINATION TREATMENT OF LOCALLY ADVANCED NON-SMALL-CELL LUNG CANCER	2010	Aminodov Sergej Aleksandrovich Gel'Fond Mark L'Vovich	RU2444384C1
TETRA(PYREN-1-YL)TETRACYANOPORPHYRAZINE AS A MULTIFUNCTIONAL AGENT FOR THERAPY OF MALIGNANT GROWTHS	2019	Lermontova Svetlana Alekseevna Klapshina Larisa Grigorevna Balalaeva Irina Vladimirovna Ladilina Elena Yurevna Lyubova Tatyana Sergeevna Grigorev Ilya Sergeevich	RU2725641C1
METHOD FOR EARLY DIAGNOSTICS OF CERVICAL INTRAEPITHELIAL NEOPLASIAS (CIN) BASED ON METABOLIC MARKERS STUDY	2016	Khlebkova Yuliya Sergeevna Vishnyakova Polina Aleksandrovna Mezhevitinova Elena Anatolevna Vysokikh Mikhail Yurevich	RU2629632C1
TETRA(BENZOTHIOPHEN-2-YL)TETRACYANOPORPHYRAZINE AS MULTIMODAL PHOTODYNAMIC THERAPY AGENT	2018	Lermontova Svetlana Alekseevna Klapshina Larisa Grigorevna Balalaeva Irina Vladimirovna Ladilina Elena Yurevna Grigorev Ilya Sergeevich	RU2684623C1

RU 2 463 963 C1

Authors

Shvartsburd Polina Mikhajlovna

Aslanidi Konstantin Borisovich

Dates

2012-10-20—Published

2011-07-26—Filed