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2 464 310

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IPC

C12N7/00(2006-01-01)

A61K39/145(2006-01-01)

A61P31/00(2006-01-01)

(21) (22)

Application

2011124699/10, 2011-06-16

(24)

Start date

2011-06-16

(22)

Actual filing date

2011-06-16

(45)

Published

2012-10-20

(72)

Inventor

Desheva Julija AndreevnaRudenko Larisa GeorgievnaAleksandrova Galina Ibragimovna

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Institut Ehksperimental'Noj Meditsiny" Szo Ramn

REASSORTANT A/17/NEW CALEDONIA/99/79(H1N1) INFLUENZA VIRUS STRAIN FOR PRODUCING LIVE INFLUENZA INTRANASAL VACCINE Russian patent published in 2012 - IPC C12N7/00 A61K39/145 A61P31/00

Abstract RU 2464310 C1

FIELD: medicine.

SUBSTANCE: what is presented is the reassortant A/17/New Caledonia/99/76(H1N1) vaccine strain of influenza A virus. Said strains replicates actively in growing chicken embryos at optimum temperature 33°C; it is characterised by thermal sensitivity, cold adaptation and attenuation for laboratory animals. The reassortant has inherited the genes coding surface glycoproteins - hemagglutinin and neuraminidase from an epidemic type A(H1N1) virus, and and six genes coding non-glycosylated proteins from the attenuation donor A/Moscow/21/17/65(H2N2). Thereby the A/17/New Caledonia/99/76(H1N1) vaccine strain has such genome formula and biological properties to meet the requirements for the vaccine strains for live influenza vaccines according to the Manufacturer's Monograph 42-0417.

EFFECT: invention may be used in public health service for prevention of influenza infection caused by the epidemic influenza virus strain.

4 tbl, 2 ex

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RU 2 464 310 C1

Authors

Desheva Julija Andreevna

Rudenko Larisa Georgievna

Aleksandrova Galina Ibragimovna

Dates

2012-10-20—Published

2011-06-16—Filed