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2 556 834

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(51)

IPC

C07K7/00(2006-01-01)

A61K39/145(2006-01-01)

(21) (22)

Application

2011128994/10, 2011-07-12

(24)

Start date

2011-07-12

(22)

Actual filing date

2011-07-12

(45)

Published

2015-07-20

(72)

Inventor

Isakova-Sivak Irina NikolaevnaRudenko Larisa Georgievna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Severo-Zapadnogo Otdelenija Ramn Szo Ramn)

USING INFLUENZA VIRUS STRAIN A/17/NEW CALEDONIA/99/145 (H1N1) AS ATTENUATION DONOR FOR PRODUCING VACCINATING STRAINS OF LIVING INFLUENZA VACCINE SUBTYPE H2N2, VACCINATING INFLUENZA VIRUS STRAINS A/17/CALIFORNIA/66/4412 (H2N2) AND A/17/TOKYO/67/912 (H2N2) (VERSIONS) Russian patent published in 2015 - IPC C07K7/00 A61K39/145

Abstract RU 2556834 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to virology and concerns the influenza virus strain A/17/New Caledonia/99/145 (H1N1) used as an attenuation donor, as well as vaccinating strains A/17/California/66/4412 (H2N2) and A/17/Tokyo/67/912 (H2N2). The presented vaccinating strains are reassortants and produced by crossing the epidemic viruses A/California/1/66 (H2N2) and A/Tokyo/3/67(H2N2) respectively with the strain A/17/New Caledonia/99/145 (H1N1). The presented strains A/17/California/66/4412 (H2N2) and A/17/Tokyo/67/912 (H2N2) are deposited in D. I. Ivanovskiy's Institute of Virology, under Nos. 2650 and 2651 respectively. The reassortants have inherited two genes coding surface virus antigen (haemaglutinin and neuraminidase) from the epidemic viruses A/California/1/66 (H2N2) and A/Tokyo/3/67(H2N2) respectively, and the rest six genes coding nonglycosylated proteins from the attenuation donor A/17/New Caledonia/99/145 (H1N1).

EFFECT: presented inventions enable producing the vaccinating strains to be used in preparing the intranasal vaccines.

3 cl, 2 tbl

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RU 2 556 834 C2

Authors

Isakova-Sivak Irina Nikolaevna

Rudenko Larisa Georgievna

Dates

2015-07-20—Published

2011-07-12—Filed