FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing therapeutically useful triphenyl butene derivatives of formula (Ia) 
or (lb) 
in which a compound of formula (II) 
is alkylated with an alkylating agent of formula X-(CH2)2-O-(CH2)2-O-Pr or formula X-(CH2)2-O-Pr, respectively, where X is Cl, Br, I, mesyloxy or tosyloxy, and Pr is a protective group, to obtain a compound of formula (III) 
or formula (IV) 
from which the protective group Pr is removed to obtain the desired compounds in form of Z-isomers. The present invention also relates to a method of producing a compound of formula (Ib) in form of a Z-isomer, in which the compound of formula (II) is alkylated with an alkylating agent of formula X-CH2-COOR, where X is Cl, Br, I, mesyloxy or tosyloxy, and R is an alkyl, to obtain a compound of formula (V) 
and ester group V is reduced to obtain the end product.
EFFECT: improved method.
23 cl, 7 ex
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