NEW SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS AS INDOLEAMINE-2,3-DIOXYGENASE AND/OR TRYPTOPHAN-2,3-DIOXYGENASE INHIBITORS Russian patent published in 2021 - IPC C07D519/00 A61K31/437 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of imidazopyridine of formula (I),

where: each of R¹ and R² is H; one of R³ and R⁶ is H, and the other is Y¹; each of R⁴ and R⁵ is independently selected from a group consisting of (1) H, (2) halogen, (3) C_1-6-alkyl, optionally substituted with one to three halogen atoms, and (4) C_1-6-alkoxy, optionally substituted with one to three halogen atoms; Y¹ is a group having the following formula:

the dotted line is an optional double bond; Q is -C(R^a)(R^a')-, -N(R^a)- or -O-; T is -C (R^a)(R^a')- or -N(R^a)-; R^a is selected from a group consisting of (1) H, (2) C_1-6-alkyl, and (3) phenyl; wherein each of alkyl and phenyl is optionally substituted with one substitute independently selected from halogen and 6-member heteromonocyclic group containing one ring heteroatom, selected from oxygen; R^a' is selected from a group consisting of (1) H and (2) C_1-6-alkyl; R^b represents C 1-6 -alkyl; each of R c and R d is independently selected from a group consisting of (1) H, (2) C_1–6-alkyl, and (3) oxo; m is 0, 1 or 2; n equals 0, 1 or 2; and p is 0 or 1, which are inhibitors of indolamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes; also disclosed is use of compounds in potential treatment or prevention of development of IDO- and/or TDO-associated disease or disorder, compositions containing these compounds, and use of compounds in potential treatment or prevention of developing IDO- and/or TDO-associated disease or disorder.

EFFECT: novel substituted imidazopyridine compounds as inhibitors of indolamine-2,3-dioxygenase and/or tryptophan-2,3-dioxygenase.

17 cl, 32 ex, 6 tbl