FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a compound represented by the structure of formula I, where T represents OH; R1 is CH3; Y is H, CF3, F, I, Br, Cl or CN; Z is H, NO2, CN, halide, COOH, COR, NHCOR or CONHR; X is CH or N; R represents H, C1-C6 alkyl or CH2Cl; A is R2; R2 is a pyrazole, imidazole or triazole ring unsubstituted or substituted with at least one of Q1, Q2, Q3 or Q4 each independently selected from hydrogen, linear or branched C1-C6 alkyl, C1-C6 haloalkyl, phenyl, F, Cl, Br, I, CN, NO2, OR, benzyl, NHCOOR, N(R)2, NHCOR, CONHR, COOR or COR; where the specified phenyl is not substituted or substituted by halogen; or its optical isomer or pharmaceutically acceptable salt. The invention relates to a pharmaceutical composition having selective androgen receptor disruption (SARD) activity, containing a therapeutically effective amount of a SARD compound of the invention, or an optical isomer or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
EFFECT: compounds that selectively destroy androgen receptors (SARD) based on pyrazole, imidazole, triazole for use in the treatment of prostate cancer, prostate cancer resistant to enzalutamide and abiratrenone, cancer sensitive to androgen receptors (AR).
23 cl, 4 tbl, 49 dwg, 10 ex
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Authors
Dates
2023-05-03—Published
2017-06-12—Filed