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2 465 272

(13)

(51)

IPC

C07D333/38(2006-01-01)

C07D409/12(2006-01-01)

A61K31/381(2006-01-01)

A61P19/02(2006-01-01)

A61P25/28(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2010112967/04, 2008-08-15

(24)

Start date

2008-08-15

(22)

Actual filing date

2008-08-15

(45)

Published

2012-10-27

(72)

Inventor

Veliselebi GonulStoderman Kennet A.Plejnet Dehvid P.M.Cheng SoanUitten Dzheffri P.

(73)

Holder

Kalsimedika, Ink.

COMPOUNDS MODULATING INTRACELLULAR CALCIUM Russian patent published in 2012 - IPC C07D333/38 C07D409/12 A61K31/381 A61P19/02 A61P25/28 A61P29/00

Abstract RU 2465272 C2

FIELD: medicine.

SUBSTANCE: invention refers to a compound of formula (I) or to its pharmaceutically acceptable salt: formula (I) wherein; R¹ represents hydrogen; R² represents phenyl, benzothienyl, benzofuranyl or the group -CH₂CH₂-phenyl; wherein R² is optionally substituted by 1 or 2 substitutes optionally specified in F, O, Br, I, -CN, -NO₂, -OR⁸, C₁-C₆alkyl and -N(R⁹)₂; R⁴ represents phenyl substituted by 1 or 2 substitutes optionally specified in F, CI, Br, I, -CP₃, -OH, -OR⁸ and C₁-C₆alkyl; each R⁸ is optionally specified in C₁-C₆alkyl; and each R⁹ is optionally specified in H and C₁-C₆alkyl. The invention also refers to a pharmaceutical composition for activity modulation of depot-controlled calcium channels (SOC-channels) containing such compounds.

EFFECT: there are produced new compounds and based pharmaceutical compositions which can find application in medicine for treating the diseases or conditions, such as rheumatoid arthritis, psoriasis, inflammatory intestinal disease, asthma and multiple sclerosis.

12 cl, 21 dwg, 1 tbl, 14 ex

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RU 2 465 272 C2

Authors

Veliselebi Gonul

Stoderman Kennet A.

Plejnet Dehvid P.M.

Cheng Soan

Uitten Dzheffri P.

Dates

2012-10-27—Published

2008-08-15—Filed