PAI-1 BINDING MODULATORS FOR TREATMENT OF EYE DISEASES Russian patent published in 2012 - IPC A61K31/19 A61K31/122 A61K31/403 A61K31/395 A61P27/00 A61P27/06 

Abstract RU 2465898 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to ophthalmology and can be used for treatment of glaucoma or higher intraocular pressure (IOP) in patient. For this purpose efficient amount of composition, containing preparation inhibiting PAI-1 binding with vitronectin, is introduced to patient. Also claimed is method of treating PAI-1-associated eye disease.

EFFECT: group of inventions ensures treatment of glaucoma and IOP due to reduction of separation of trabecular meshwork tissue and reduction of increased resistance to intraocular fluid outflow, and also due to increase of TM tissue cellularity and preservation of phagocytosis.

14 cl, 8 dwg, 8 ex

Similar patents RU2465898C2

Title Year Author Number
ANTAGONISTS CDK2 AS ANTAGONISTS OF SHORT FORM OF C-MAF TRANSCRIPTION FACTOR FOR GLAUCOMA TREATMENT 2004
  • Shepard Allan R.
  • Dzhejkobson Nasrin
  • Klark Ehbbot F.
RU2370267C2
AGENTS ADJUSTING, INHIBITING OR MODULATING ACTIVITY AND/OR EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTORS (CTGF) AS UNIQUE DRUGS FOR INTRAOCULAR TENSION REDUCTION AND TREATMENT OF GLAUCOMA RETINOPATHIES/OPTICAL NEUROPATHIES 2003
  • Flinor Debra L.
  • Shepard Allan
  • Dzhejkobson Nasrin
  • Pan Iok-Khou
  • Klark Ehbbot F.
RU2332213C2
MEDIATED PHKi INHIBITION OF Rho-KINASE FOR TREATING OPHTHALMIC DISORDERS 2006
  • Chatterton Dzhon E.
  • Klark Ehbbot F.
RU2432165C2
NOVEL NRP-B AGONISTS 2010
  • Osterkamp Frank
  • Khavlish Khajko
  • Khummel' Gerd
  • Knaute Tobias
  • Rajmer Ul'F
  • Rajneke Ul'Rikh
  • Rikhter Uve
  • Zimon Bernadett
  • Shpeker Ehdgar
  • Vojshnik Markus
  • Khellberg Mark R.
RU2557290C2
NEW NPR-B AGONISTS 2010
  • Osterkamp Frank
  • Khavlish Khajko
  • Khummel Gerd
  • Knaute Tobias
  • Rajmer Ulf
  • Rajneke Ulrikh
  • Rikhter Uve
  • Zimon Bernadett
  • Shpeker Edgar
  • Vojshnik Markus
  • Khellberg Mark R.
RU2636738C2
APPLICATION OF SERUM AMYLOID A GENE FOR DIAGNOSIS AND THERAPY OF GLAUCOMA AND IDENTIFICATION OF ANTIGLAUCOMATOUS AGENT 2007
  • Klark Ehbbot F.
  • Van Van'-Khehn
  • Maknatt Loretta Grejvz
RU2461378C2
siPHK-BASED TREATMENT OF EYE DISEASE CHARACTERISED BY HIGH INTRAOCULAR PRESSURE 2005
  • Khimenes Ana I.
  • Sesto Ankhela
  • Roman Khose P.
  • Gaskon Irehn
  • Gonsales De Buitrakho Gonsalo
RU2407531C2
APPLICATION OF SERUMAL AMYLOID GENE A IN DIAGNOSTICS AND TREATMENT OF GLAUCOMA AND DETERMINATION OF ANTIGLAUCOMA AGENTS 2004
  • Klark Ehbbot F.
  • Van Van'-Khehn
  • Maknatt Loretta
RU2365379C2
TREATMENT OF EYE DISEASES SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY WITH MEDICATIONS THAT ELIMINATE AGING CELLS 2018
  • Hopkins, Jill
  • Tsuruda, Pam
  • Chapman, Claude
  • Sweigard, Harry
  • Poon, Yan
  • Marquess, Daniel
  • David, Nathaniel
  • Dananberg, Jamie
  • Laberge, Remi-Martin
RU2815482C2
GLAUCOMA TREATMENT 2018
  • Bruce Lars
  • Bruce Adam
RU2759998C2

RU 2 465 898 C2

Authors

Flinor Debra

Pan Iok-Khou

Klark Ehbbot

Dates

2012-11-10Published

2007-10-31Filed