siPHK-BASED TREATMENT OF EYE DISEASE CHARACTERISED BY HIGH INTRAOCULAR PRESSURE Russian patent published in 2010 - IPC A61K31/70 A61P27/02 

Abstract RU 2407531 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to biology and medicine. A drug is prepared for local application on a corneal surface. As targets, there are offered to be used carbonic anhydrase II, IV and XII, adrenergic receptors: beta 1 and 2, and alpha IA, IB and ID, acetylcholinesterase, cyclooxygenases 1 and 2, ATP-ases: alpha-1, alpha-2, alpha-3, beta-1, beta-2, an endothelial leukocyte adhesion molecule (ELAM-1), angiotensin I conveting enzymes (ACE I and ACE II), angiotensin I receptors (ATR1 and ATR2) and renin; cochline.

EFFECT: application of RNA interference technique in treating eye diseases, preferentially glaucoma and uveitis.

36 cl, 2 tbl, 2 ex, 3 dwg

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RU 2 407 531 C2

Authors

Khimenes Ana I.

Sesto Ankhela

Roman Khose P.

Gaskon Irehn

Gonsales De Buitrakho Gonsalo

Dates

2010-12-27Published

2005-08-23Filed