AMINONICOTINIC ACID AND ISONICOTINIC ACID DERIVATIVES AS DHODG (DIHYDROOROTATE DEHYDROGENASE) INHIBITORS Russian patent published in 2012 - IPC C07D213/79 C07D213/80 A61K31/465 A61P35/00 A61P19/00 A61P19/02 A61P17/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new compounds of formula (I) and its pharmaceutically acceptable salts possessing dihydroorotate dehydrogenase inhibitory ability, to a based pharmaceutical composition, to application thereof in preparing a drug compound and to a combined preparation containing the presented compounds and the other active compound (I) in effective amounts wherein both groups G¹ mean CR^C, G² mean a nitrogen atom or group CR^d, of the groups G³ and G⁴ mean a nitrogen atom and the other one means group CH, M means a hydrogen atom or a pharmaceutically acceptable cation, while R¹, R², R^a, R^b, R^c and R^d have the values specified in the patent claim.

EFFECT: preparing pharmaceutically acceptable salts possessing dihydroorotate dehydrogenase inhibitory ability.

25 cl, 115 ex, 2 tbl