FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to novel 11,11-dimethyl-1-oxo-1,2,10,11-tetrahydrobenzo[h]pyrrolo[2,1-a]-isoquinoline-2-spiro-2-(1-aryl-3-aroyl-4-hydroxy-5-oxo-2,5-dihydropyrroles) of the formulae (Ia-d): 
wherein Ar means Ph (Ia, b), C6H4OEt-4 (Ic), C6H4Cl-4 (Id); Ar' means C6H4Me-4 (Ia, c, d), C6H4Cl-4 (Ib) that elicit antibacterial activity against gram-positive microflora. Compounds of the formula (I) are prepared by interaction of 1-aryl-4-aroyl-5-methoxycarbonyl-2,3-dihydro-2,3-pyrrolidones with 1,3,3-trimethyl-3,4-dihydrobenzo[f]isoquinoline in absolute benzene medium at boiling for 2 min followed by isolation of end products by the known procedures. Synthesized compounds are not toxic practically.
EFFECT: improved preparing method, valuable biological properties of compounds.
1 tbl, 1 sch, 2 ex
| Title |
Year |
Author |
Number |
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2006 |
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|
RU2316557C1 |
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|
RU2294330C1 |
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2007 |
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2003 |
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RU2238272C1 |
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2007 |
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RU2792621C1 |
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2016 |
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