5-METHYL-2-OXO-1-PHENYL-4-ETHOXYCARBONYL-2,3-DIHYDRO-1H-PYRROLE-3-SPIRO-2-(3-BENZOYL-4-HYDROXY-1-ORTHO-HYDROXYPHENYL-5-OXO-2,5-DIHYDROPYRROLES) ELICITING ANTIMICROBIAL ACTIVITY WITH RESPECT TO GRAM-POSITIVE MICROFLORA AND METHOD FOR THEIR PREPARING Russian patent published in 2007 - IPC C07D487/10 A61P31/00 

Abstract RU 2294330 C1

FIELD: organic chemistry, microbiology.

SUBSTANCE: invention relates to novel 5-methyl-2-oxo-1-phenyl-4-ethoxycarbonyl-2,3-dihydro-1H-pyrrole-3-spiro-2-(3-benzoyl-4-hydroxy-1-o-hydroxyphenyl-5-oxo-2,5-dihydropyrroles) of the formula (IIIa,b): wherein X means -OCH3; Y means -CH3 (IIIa); X means bromine atom (Br); Y means chlorine atom (Cl) (IIIb). Proposed compounds elicit an antimicrobial activity with respect to gram-positive microflora. Also, invention describes a method for their synthesis.

EFFECT: valuable biological property of compounds.

3 cl, 1 sch, 1 tbl, 3 ex

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RU 2 294 330 C1

Authors

Maslivets Andrej Nikolaevich

Racheva Nadezhda L'Vovna

Belevich Irina Olegovna

Dates

2007-02-27Published

2005-10-11Filed