FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to use of 4'-hydroxy-1'-(2-hydroxyalkyl)-3'-aroyl-6,6-dimethyl-6,7-dihydrospiro[indole-3,2'-pyrrole]-2,4,5'(1H,1'H,5H)-trions of general formula
,
where Ar = 4-MeC6H4, R1 = H, R2 = Ph (a); Ar = 4-MeC6H4, R1 = H, R2 = C6H5CH2 (b); Ar = 4-BrC6H4, R1 = H, R2 = 4-BrC6H4 (c); Ar = 4-BrC6H4, R1 = H, R2 = C6H5CH2 (d); R1 = Me, Ar = 4-ClC6H4, R2 = cyclohexyl (e), as agents having bactericidal activity against S. aureus bacteria.
EFFECT: antimicrobial activity against bacteria Staphylococcus aureus of compounds of spiro[indole-3,2'-pyrroles] class.
1 cl, 1 tbl, 6 ex
| Title |
Year |
Author |
Number |
| 3'-AROYL-1-BENZYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)-6,6-DIMETHYL-6,7-DIHYDROSPIRO[INDOLO-3,2'-PYRROLE]-2,4,5'(1H,1'H,5H)-TRIONES POSSESSING ANALGESIC ACTIVITY AND A METHOD FOR THEIR PREPARATION |
2018 |
- Tretyakov Nikita Alekseevich
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- Makhmudov Ramiz Ragibovich
- Galeev Andrej Ruslanovich
|
RU2688931C1 |
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2021 |
- Maslivets Andrej Nikolaevich
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- Makhmudov Ramiz Ragibovich
|
RU2763738C1 |
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2012 |
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|
RU2520005C2 |
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2019 |
- Tretyakov Nikita Alekseevich
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|
RU2707196C1 |
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2022 |
- Maslivets Andrei Nikolaevich
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|
RU2790479C1 |
| THE USE OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-2-THIOXO-1,3,6-TRIAZASPIRO[4.4]NON-8-EN-4,7-DIONES AS AGENTS WITH ANTIMICROBIAL ACTIVITY AGAINST S. AUREUS |
2022 |
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2023 |
- Maslivets Andrei Nikolaevich
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|
RU2798423C1 |
| APPLICATION OF 3'-AROYL-4'-HYDROXY-1'-(2-HYDROXYETHYL)SPIRO[BENZO[b][1,4]THIAZINE-2,2'-PYRROLE]-3,5'(1'H,4 H)-DIONES AS AGENTS WITH ANALGESIC ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
- Tretyakov Nikita Alekseevich
- Makhmudov Ramiz Ragibovich
|
RU2775547C1 |
| 1,1'-DIARYL-3'-AROYL-4'-HYDROXY-1H-SPIRO [INDENO[1,2-b]PYRROL-3,2'-PYRROL]-2,4,5'-(1'H)-TRIONES AND METHOD OF THEIR OBTAINING |
2011 |
- Bubnov Nikolaj Vladimirovich
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- Makhmudov Ramiz Ragibovich
- Maslivets Andrej Nikolaevich
|
RU2467011C1 |
| USE OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-1,3-DIPHENYL-1,3,6-TRIAZASPIRO[4,4]NON-8-ENE-2,4,7-TRIONES AGENTS WITH ANTIMICROBIAL ACTIVITY AGAINST S. AUREUS CULTURE |
2023 |
- Tretiakov Nikita Alekseevich
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|
RU2813484C1 |
