FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely new organic compounds, namely N,N'-substituted piperazines of general formula 
(I), wherein R1, R2: linear or branched alkoxy (C1÷C4), CH3C(=O)O; n=1-5; m=0-3; Z: C=O, SO2; X:C(=NH)NH2, C(=NH)NHC(-NH)NH2, G is low-molecular organic or mineral acid, sodium, potassium, ammonium cations or water influences the haemostasis system, showing antiagregant, anticoagulant and vasodilator properties, and to a method for preparing N,N'-substituted piperazines of formula 1 by reaction of N-substituted piperazines of general formula 
wherein R1, R2; linear or branched alkoxy (C1÷C4), CH3C(=O)O; n=1-5; m=0-3; Z: C=O, SO2; and 1H-pyrazole-1-carboxamidine, dicyane diamide and their salts in organic solvents or water at temperature 10-50°C in the presence of bases.
EFFECT: new substance are promising for prevention and treatment of the disturbed haemostasis system.
12 cl, 10 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTANCE HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATOR ACTIVITY, AND METHOD OF PRODUCING N, N '-SUBSTITUTED PIPERAZINES | 2014 |
|
RU2577039C2 |
| 0 |
|
SU439983A1 | |
| NOVEL CARBOXY-SUBSTITUTED CYCLIC DERIVATIVES OF CARBOXAMIDE | 1997 |
|
RU2199535C2 |
| METHOD OF SYNTHESIS OF N-ACRYLOYLPIPERAZINE DERIVATIVES | 1990 |
|
RU2024513C1 |
| DERIVATIVES OF SPIROPIPERIDINE, MEDICINAL AGENT, METHOD OF PROPHYLAXIS OR TREATMENT | 1999 |
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RU2184735C2 |
| DIPEPTIDE-NITRILE INHIBITORS OF CATHEPSIN K | 2001 |
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RU2293732C2 |
| DIPEPTIDE NITRILE INHIBITORS OF CATHEPSIN K | 2001 |
|
RU2265601C2 |
| DERIVATIVES OF ALPHA-(N-SULFONAMIDO)ACETAMIDE AS INHIBITORS OF BETA-AMYLOID | 2002 |
|
RU2300518C2 |
| METHOD OF HETRAZEPINE DERIVATIVES SYNTHESIS | 0 |
|
SU1738089A3 |
| N-HYDROXYFORMAMIDE COMPOUNDS AS METALLOPROTEINASE INHIBITORS | 2004 |
|
RU2351595C2 |
