FIELD: organic chemistry. SUBSTANCE: product - derivatives of N-acryloylpiperazine of the formula (I), where R1 and R2 are similar or different and mean: phenyl unsubstituted or substituted with 1-2 substituents taken from the halide group, C1-C4-alkyl, (C-C)-alkoxy, trifluoromethyl, cyano-group, or naphthyl or thienyl-radical; n = 2 or 3; R3-C1-C4-alkoxy or one of R3-C1-C4-alkoxy or one of R3-hydroxy, and the rest - C1-C4-alkoxy. Reagent 1: (R1R2)C=CH-C(O)-Z1 where Z1 - nucleophilic removable group. Reagent 2: compound of the formula (III), where Z2 - a group of the formula (IV), or inversely. Compounds show antagonistic activity with respect to PAF. EFFECT: improved method of synthesis. 8 tbl
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