FIELD: chemistry.
SUBSTANCE: invention relates to N, N′-substituted piperazines of formula I and a method of producing compounds of formula II. Said compounds affect hemostasis system and exhibit antiplatelet, anticoagulant and vasodilatory properties. In general formula (I) R1 - linear or branched alkyl C1-C4, R2 - linear or branched alkyl C5-C12, G - mineral or organic C1-C4 acid or water, in general formula II R1 - linear or branched alkyl C1-C4, R2 - linear or branched alkyl C1-C12, G - mineral or organic C1-C4 acid or water.
EFFECT: disclosed method enables to obtain compounds of formula II with purity of over 99 % and content of individual impurities not more than 1/10 % and sum of impurities of not more than 5/10 %.
11 cl, 2 dwg, 6 tbl, 13 ex
Title | Year | Author | Number |
---|---|---|---|
SUBSTANCE SHOWING COMBINED ANTIAGREGANT, ANTICOAGULANT AND VASODILATOR ACTIVITIES, N,N'-SUBSTITUTED PIPERAZINES AND METHOD FOR PREPARING THEM (VERSIONS) | 2010 |
|
RU2469029C2 |
METHOD FOR SYNTHESIS OF CHIRAL N-ARYLPIPERAZINES | 2003 |
|
RU2315762C2 |
METHOD OF PRODUCING N-ADAMANTYLATED AMIDES | 2013 |
|
RU2549901C1 |
NOVEL 2',5'-DIARYLSPIRO[INDOLE-3,3'-PYRROLIDINE]-2(1H)-ONES AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2730287C1 |
METHOD OF SYNTHESIS OF N-ACRYLOYLPIPERAZINE DERIVATIVES | 1990 |
|
RU2024513C1 |
METHOD OF PRODUCING 3-ARYL-1H-BENZO[f]CHROMENE DERIVATIVES | 2014 |
|
RU2597363C2 |
METHOD FOR PREPARING CHIRAL 1,4-DISUBSTITUTED PIPERAZINES | 2003 |
|
RU2315044C2 |
UV/VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS | 2009 |
|
RU2503667C2 |
FLUOROQUINOLONE COMPOUNDS BASED ON PYRIDOXINE DERIVATIVES, HAVING ANTIBACTERIAL PROPERTIES | 2019 |
|
RU2713932C1 |
ARYLMETHOXY ISOINDOLIN DERIVATIVE, COMPOSITIONS INCLUDING THEREOF AND METHODS OF THEIR APPLICATION | 2011 |
|
RU2567753C2 |
Authors
Dates
2016-03-10—Published
2014-02-28—Filed