SUBSTANCE HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATOR ACTIVITY, AND METHOD OF PRODUCING N, N '-SUBSTITUTED PIPERAZINES Russian patent published in 2016 - IPC C07D295/192 A61K31/495 A61P9/08 A61P9/10 A61P7/02 

Abstract RU 2577039 C2

FIELD: chemistry.

SUBSTANCE: invention relates to N, N′-substituted piperazines of formula I and a method of producing compounds of formula II. Said compounds affect hemostasis system and exhibit antiplatelet, anticoagulant and vasodilatory properties. In general formula (I) R1 - linear or branched alkyl C1-C4, R2 - linear or branched alkyl C5-C12, G - mineral or organic C1-C4 acid or water, in general formula II R1 - linear or branched alkyl C1-C4, R2 - linear or branched alkyl C1-C12, G - mineral or organic C1-C4 acid or water.

EFFECT: disclosed method enables to obtain compounds of formula II with purity of over 99 % and content of individual impurities not more than 1/10 % and sum of impurities of not more than 5/10 %.

11 cl, 2 dwg, 6 tbl, 13 ex

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RU 2 577 039 C2

Authors

Veselkina Olga Sergeevna

Borovitov Maksim Evgenevich

Galenko Aleksej Viktorovich

Nilov Denis Igorevich

Dates

2016-03-10Published

2014-02-28Filed