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2 469 726

(13)

(51)

IPC

A61K31/573(2006-01-01)

A61K47/34(2006-01-01)

A61K47/04(2006-01-01)

A61K9/08(2006-01-01)

A61P27/16(2006-01-01)

(21) (22)

Application

2010150863/15, 2009-05-14

(24)

Start date

2009-05-14

(22)

Actual filing date

2009-05-14

(45)

Published

2012-12-20

(72)

Inventor

Likhter DzhejFoll'Rat BenediktTrehmmel Ehndrju M.Djuron Sergio G.P'Ju FabrisDellamehri Luis A.E TsjanLebel KarlSkajf Majkl KristoferKharris Dzheffri P.

(73)

Holder

Otonomi, Ink.Dze Regents Of Dze Juniversiti Of Kalifornija

CORTICOSTEROID-BASED COMPOSITION WITH CONTROLLED RELEASE FOR TREATMENT OF EAR DISEASES Russian patent published in 2012 - IPC A61K31/573 A61K47/34 A61K47/04 A61K9/08 A61P27/16

Abstract RU 2469726 C2

FIELD: medicine.

SUBSTANCE: pharmaceutical composition, suitable for application in treatment of ear diseases includes acceptable for ear thermoreversable water gel. Pharmaceutical composition consists of anti-inflammatory corticosteroid in form of multiple particles and polyoxypropylene and polyoxyethylene-based polymer. Composition is introduced locally to the subject, suffering from ear disease, by intratympanic introduction on membrane of cochlea window or near it.

EFFECT: composition in accordance with invention ensures prolonged release of anti-inflammatory corticosteroid through membrane of cochlea window into inner ear cochlea during, at least, 5 days after a single introduction.

12 cl, 9 dwg, 9 tbl, 31 ex

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RU 2 469 726 C2

Authors

Likhter Dzhej

Foll'Rat Benedikt

Trehmmel Ehndrju M.

Djuron Sergio G.

P'Ju Fabris

Dellamehri Luis A.

E Tsjan

Lebel Karl

Skajf Majkl Kristofer

Kharris Dzheffri P.

Dates

2012-12-20—Published

2009-05-14—Filed