FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to a method for preparing derivatives of indole of the general formula (I):
wherein R1 represents hydroxy-group; R2 represents hydrogen atom, (C1-C6)-alkyl, (C1-C6)-alkoxy-group, (C2-C6)-alkoxyalkyl or 4-methoxybenzyl; R3 represents hydrogen atom or (C1-C6)-alkyl; each among R4 and R represents independently hydrogen atom, (C1-C6)-alkyl or (C1-C6)-alkoxy-group; D represents an ordinary bond, (C1-C6)-alkylene, (C2-C6)-alkenylene or (C1-C6)-oxyalkylene; in the group-G-R6 wherein G represents an ordinary bond, (C1-C6)-alkylene; R represents saturated or unsaturated carbocyclic ring (C3-C15) or 4-15-membered heterocyclic ring comprising 1-5 atoms of nitrogen, sulfur and/or oxygen wherein this ring can be substituted. Also, invention describes a method for preparing derivatives of indole and DP-receptor antagonist comprising derivative of the formula (I) as an active component. As far as compounds of the formula (I) bind with DP-receptors and they are antagonists of DP-receptors then they can be useful for prophylaxis and/or treatment of diseases, for example, allergic diseases.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
11 cl, 7 tbl, 353 ex
| Title |
Year |
Author |
Number |
| 8-AZAPROSTAGLANDINE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND AGENT FOR PROPHYLAXIS OF DISEASES |
2003 |
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- Marujama Toru
- Kambe Tokhru
- Ogava Mikio
- Siroja Tsutomu
|
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2001 |
- Tadzima Khisao
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|
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2004 |
- Asada Masaki
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- Narita Masami
- Sato Kazutojo
- Kinosita Atsusi
- Nagase Tosikhiko
- Esikava Ken
|
RU2335490C2 |
| DERIVATIVE OF CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION AND MEDICINE OF PREVENTING AND/OR CURING DISEASES, CAUSED BY ACTIVATION OF DP RECEPTOR, USE OF SUCH DERIVATIVE FOR MAKING SUCH MEDICINE, METHOD OF PREVENTING AND/OR CURING DISEASES, CAUSED BY ACTIVATION OF DP RECEPTORS |
2003 |
- Ivakhasi Maki
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- Nambu Fumio
|
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| DERIVATIVES OF CARBOXYLIC ACIDS AND PHARMACEUTICAL AGENT COMPRISING THEIR AS ACTIVE COMPONENT |
2002 |
- Tani Kosuke
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|
RU2315746C2 |
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2002 |
- Naganava Atsusi
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|
RU2299202C2 |
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2004 |
- Kusuda Sinija
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| DERIVATIVES OF AROYLPIPERAZINE, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT |
1998 |
- Mijake Khirosi
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- Eikiu Jositeru
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- Manabe Takasi
- Konisi Nobukijo
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|
RU2258702C2 |
| DERIVATIVES OF 3,4-DIHYDROISOQUINOLINE AND PHARMACEUTICAL AGENT COMPRISING ITS AS ACTIVE COMPONENT |
2001 |
- Ogava Mikio
- Takaoka Esikazu
- Okhkhata Akira
|
RU2272030C2 |
| 1',2',3'-TRIMETHOXYBENZO[4',5':4,5]-6,7-DIHYDROCYCLOHEPTA-[3,2-f]-1H-1-METHYL INDOLE DERIVATIVE AND USE THEREOF |
2012 |
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