FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to pharmaceutics. First invention represents a tablet containing: (a) an extrudate, including: (i) a polymer matrix which is a water-soluble copolymer of vinylpyrrolidone and vinyl acetate; (ii) a dispersant; and (iii) a compound of formula I or a pharmaceutically acceptable salt thereof:
Formula I
where Ra is independently -H or -F, wherein dispersing agent and compound of Formula I are dispersed in said polymer matrix; and (b) a disintegrating system comprising powdered sodium chloride and sodium croscarmellose. Second invention is a composition suitable for pressing into a tablet, and a third invention is a tablet with tensile strength of 1.75 MPa, obtained by pressing said composition.
EFFECT: technology of preparing tablets for cgrp-active compounds is disclosed.
19 cl, 3 dwg, 2 tbl, 2 ex
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