AMINE DERIVATIVES AND USE THEREOF IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES Russian patent published in 2013 - IPC C07D265/36 C07C237/08 C07C237/10 C07C233/04 C07C233/43 C07D209/34 C07D215/227 C07D413/12 C07D409/12 A61K31/4704 A61K31/538 A61P11/00 A61P29/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) , where Ar denotes each of R², R³, R⁴, R⁵, R⁴' and R⁵' denote hydrogen; A denotes C(O); D denotes oxygen or NR⁸; E denotes CR⁶³R⁶⁴CR⁶⁵R⁶⁶; R⁶³ and R⁶⁴ denote hydrogen; R⁶⁵ and R⁶⁶ independently denote hydrogen or C_1-4alkyl; k equals 0; m equals 1; R⁶ denotes a group -(X)_p-Y-(Z)_q-R¹⁰, or R⁶ denotes α- or β-branched C_3-6alkyl (optionally substituted with C₆cycloalkyl); X and Z independently denotes a C_1-4alkylene group; p and q are independently equal to 0 or 1; Y denotes a bond; R⁸ denotes hydrogen; R¹⁰ denotes hydrogen or a saturated 5-7-member ring system; R⁷ denotes a 6-member aromatic ring, optionally substituted with a halogen, carboxyl, C_1-6alkyl, C_1-2alkoxy or a 5-member heteroaromatic ring (which is optionally substituted with C_1-6alkyl); or a pharmaceutically acceptable salt thereof. Compounds of formula (I) or a pharmaceutically acceptable salt thereof are used to produce a medicinal agent for treating respiratory distress syndrome (ARDS), pulmonary emphysema, bronchitis, bronchiectasis, chronic obstructive pulmonary disease (COPD), asthma or rhinitis.

EFFECT: high efficiency of using said compounds.

7 cl, 1 tbl, 102 ex