BICYCLOSULPHONYL ACID (BCSA) AND USE THEREOF AS THERAPEUTIC AGENT Russian patent published in 2013 - IPC C07D275/06 C07D401/12 C07D413/10 C07D513/04 A61K31/425 A61P19/02 A61P29/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to bicyclosulphonyl acid (BCSA) compounds of formula: where: where each of -R^pw, -R^px, -R^PY, and -R^PZ independently denotes H or -R^RS1; each -R^RS1 independently denotes -F, -Cl, -Br, -I, -R^A1, -CF₃, -OH, -OCF₃ or -OR^A1; where each R^A1 independently denotes C_1-4alkyl, phenyl or benzyl; and additionally, two neighbouring -R^RS1 groups can together form -OCH₂O-, -OCH₂CH₂O- or -OCH₂CH₂CH₂O-; -R^AK independently denotes a covalent bond, -(CH₂)- or -(CH₂)₂-; -R^N independently denotes -R^NNN, or -L^N-R^NNN; the rest of the values of the radicals are given in claim 1, which act as inhibitors of inhibitors of tumor necrosis factor-α converting enzyme (TACE).

EFFECT: compounds are useful in treating TNF-α mediated conditions.

36 cl, 303 ex