NOVEL 951 COMPOUNDS: BIPHENYLOXYPROPANOIC ACID AS CRTh2 RECEPTOR MODIFIER AND INTERMEDIATE COMPOUNDS Russian patent published in 2013 - IPC C07D295/18 C07D207/02 C07C65/24 A61K31/40 A61P11/00 

Abstract RU 2472785 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) : in form of a mixture of (2S)-2-({3'-chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid and (2R)-2-({3'-3-chloro-4'-[(2,2-dimethylpyrrolidin-1-yl)carbonyl]-5-fluorobiphenyl-2-yl}oxy)propanoic acid or pharmaceutically acceptable salts thereof. Described are methods of producing said compounds, crystalline forms of the compounds and intermediate compounds. Compounds of formula I are CRTH2 receptor modulators.

EFFECT: improved method.

18 cl, 4 ex, 3 dwg

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RU 2 472 785 C2

Authors

Bonnert Rodzher Viktor

Luker Timoti Dzhon

Pehjtel Anil

Rigbi Aaron

Dates

2013-01-20Published

2008-07-01Filed