POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS Russian patent published in 2013 - IPC C08G69/10 A61K31/198 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to acids which are suitable for use in medicine, having links of formulae (I) and (II) where n equals 1 or 2; A¹ is selected from O or NR⁵, R⁵ is H or C_1-4alkyl; A² is O; R³ and R⁴ are selected from H, NH₄ or an alkali metal; R¹ and R² are selected from C_1-10alkyl, C_6-20aryl, NH₄, an alkali metal and an agent: taxane, camptothecin, doxorubicin, an acridine, coumarine, rhodamine, xanthene, cyanine or pyrene dye, a magnetic resonance imaging agent, a polydentate ligand or precursor thereof of formulae where R⁷ is selected from H, NH₄ or an alkali metal, provided that one of R¹ and R² is said agent, conjugated with a polymer directly or through a linker group, and the ratio of the agent to the polymer conjugate ranges from 1 to 50% (wt/wt).

EFFECT: compared to a polyglutamic acid conjugate, the novel biodegradable conjugate has high solubility and provides the solution with high optical transparency in a wide pH range.

53 cl, 29 dwg, 38 ex, 3 tbl