IMAGING AGENTS FOR FIBROUS DISEASES Russian patent published in 2016 - IPC A61K49/12 A61K103/00 C08G69/10 C08G69/48 

FIELD: medicine.

SUBSTANCE: invention relates to imaging agents used in non-invasive methods of fibrous disease diagnostics, fibrous disease control and method of determining effect of treating fibrotic diseases. Diagnostic technique for involves stage of visualizing agent containing retinoid and detected mark introduction in vivo, to test subject and control subject and step for comparing of signal intensity and/or distribution of mark signal detected in test subject, with change in 5-90 minutes after introduction, with change in 5-90 minutes after introduction of control signal intensity and/or distribution of reference signal mark detected in control subject.

EFFECT: methods of monitoring and determining effect of treating include stage of visualizing agent containing retinoid and detected mark administering in vivo, to subject and step of comparing signal intensity and/or distribution of mark signal, detected in first moment in time in individual with signal intensity and/or distribution of mark signal detected in said subject to second moment in time, which is later than first moment in time.

9 cl, 14 ex, 16 dwg