GLYCOLATOXIDASE INHIBITORS FOR THE TREATMENT OF DISEASES Russian patent published in 2023 - IPC C07D249/06 C07D249/04 C07D401/04 C07D401/06 C07D401/12 C07D401/14 C07D403/06 C07D403/12 C07D405/12 C07D409/12 C07D417/04 C07D417/12 A61K31/427 A61P13/00 

FIELD: chemistry.

SUBSTANCE: new chemical compounds that can be used for the treatment or prevention of diseases or disorders associated with the enzyme glycolate oxidase. A compound of formula (I) is proposed, where ring C is selected from structures (Ia) and (Ib), where wavy lines () indicate points of attachment of carbon C₁ to carbonyl C(O)-OR¹ and carbon C₂ to L; L is NR^L, S, C(=O), CH₂-Q or Q-CH₂; where Q is O, NR^L or S; R^L is hydrogen, C_1-2 alkyl or benzyl; ring A is C_4-8 cycloalkyl, C_8-11 spirocycloalkyl, 5-8 membered heterocycloalkyl containing 1-2 nitrogen atoms, imidazolyl, triazolyl, thiazolyl, thienyl, benzothiazolyl, indolinyl or isoindolinyl; ring B is present or absent; wherein: when ring B is present, then ring A is optionally substituted with methyl; when ring B is absent, then (i) ring A is substituted with one R^AB group; or (ii) ring A is unsubstituted when ring A is unsubstituted spirocycloalkyl and L is S; R^AB is halogen or C₂ or C₄ alkoxy; ring B, when present, is phenyl or quinolinyl; where each is optionally substituted with one or two R^B groups; each R^B is independently halogen; cyano; methylsulfonyl; trifluoromethyl; methoxy; C₃ alkoxy; trifluoromethoxy; cyclopropyloxy; heterocycloalkyl selected from piperidinyl, pyrrolidinyl and piperazinyl optionally substituted with methyl; or pyrazole; R¹ is hydrogen, C_1-3 alkyl or C_3-4 cycloalkyl; R² and R³ are independently hydrogen or methoxy-substituted benzyl; and optionally a pharmaceutically acceptable salt thereof. Variants of this compound are also proposed.

EFFECT: proposed compounds exhibit activity in the inhibition of glycolate oxidase.

23 cl, 6 tbl, 486 ex