FIELD: chemistry.
SUBSTANCE: described are novel trisubstituted 1,2,4-triazoles of general formula (I) (values of radicals are given in the claim) or pharmaceutically acceptable salts or hydrates or solvates thereof and a pharmaceutical composition containing said compounds. The novel compounds relate to potential positive allosteric modulators of nicotinic acetylcholine receptors, which can be used in medicine to treat psychotic disorders, intellectual impairment disorders, inflammatory diseases or conditions.
EFFECT: capacity to increase efficiency of agonists of nicotinic receptors.
9 cl, 7 tbl, 9 ex
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Authors
Dates
2013-02-10—Published
2008-10-15—Filed