FIELD: medicine.
SUBSTANCE: there are described versions of humanized monoclonal anti-factor D antibodies and their functional fragments. There are offered: a coding nucleic acid, an expression vector, as well as a cell for preparing c the antibody containing the vector. What is described is a method for preparing the anti-factor D antibody by cell culture and expressed antibody purification. Also, there are offered: an antibody composition and use of the antibody for treating disorders mediated by a complement system.
EFFECT: higher clinical effectiveness in the diseases related to excessive or uncontrolled activation of the complement system.
32 cl, 9 dwg, 4 tbl, 6 ex
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