PHARMACOLOGICAL COMPOSITION FOR INTRANASAL INTRODUCTION FOR CEREBRAL DELIVERY OF PHARMACOLOGICALLY ACTIVE COMPONENT, AND METHOD FOR PREPARING IT Russian patent published in 2013 - IPC A61K9/51 A61K9/58 A61K31/451 A61K47/02 A61K47/30 A61P25/28 A61P25/16 B82B1/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: declared group of inventions refers to a pharmacological composition for intranasal introduction for cerebral delivery, and a method for preparing said composition. The declared composition comprises a container base formed by porous particles of calcium carbonate and titanium dioxide of particle size 100-5000 nm and a pharmacologically active component - loperamide. The container surface is modified by surfactants specified in polysorbates, or by polymers specified in a group containing glycosaminoglycanes and polypeptides, or their combination. A method for preparing the pharmacological composition consists in preparing the container base by porous particle synthesis, sorption of loperamide in its pore spaces and modification of the container surface by polymers and surfactants by container incubation in their solutions.

EFFECT: invention provides preparing the pharmacological composition which is applicable for cerebral loperamide delivery after the intranasal introduction.

5 cl, 5 dwg, 1 ex