BENZENE DERIVATIVE SUBSTITUTED WITH 1,2-DI(CYCLIC GROUP) Russian patent published in 2010 - IPC C07D207/08 C07D207/404 C07D211/22 C07D211/46 C07D211/58 A61K31/495 A61K31/496 A61K31/5377 A61K31/538 A61K31/54 A61P1/04 A61P1/06 A61P29/00 A61P37/02 A61P11/06 A61P17/06 A61P19/02 

FIELD: chemistry.

SUBSTANCE: novel compounds have general formula (1), or salts thereof:

, where R¹⁰ is cyclohexyl optionally substituted with a substitute selected from group A1, or cyclohexenyl optionally substituted with a substitute selected from group A1, R³⁰, R³¹ and R³² denote hydrogen, R⁴⁰ denotes C_1-10alkyl optionally substituted with a substitute selected from group D1, n equals 0 or 1, X¹ denotes nitrogen, and R²⁰, R²¹, R²² and R²³ independently denote hydrogen, except when R²⁰, R²¹, R²² and R²³ all denote hydrogen, C_1-6 alkylthio optionally substituted with a substitute selected from group F1, C_2-6 alkoxycarbonyl, C_1-6 alkyl substituted with a substitute selected from group W1, C_1-6 alkyl substituted with a substitute selected from group K1, C_1-6 alkoxy substituted with a substitute selected from group W1, a 5-6-member heterocyclic group which is a non-aromatic saturated ring containing one or two heteroatoms selected from N or S atoms, substituted with a substitute selected from W1, a 6-member heterocyclic group which is a non-aromatic saturated ring containing one or two heteroatoms selected from N or S atoms, substituted with a substitute selected from group V1, pyridyl substituted with a substitute selected from group W1, phenyl,optionally substituted with a substitute selected from group W1, C_2-7 alkenyl, optionally substituted with a substitute selected from group W1, C_2-7 alkynyl optionally substituted with a substitute selected from group W1, a 3-6-member cycloalkyl optionally substituted with a substitute selected from group W1, a 5-6-member cyclalkenyl optionally substituted with a substitute selected from group W1, NR^1XR^2X, -CO-R^1X, -CO-NR^1XR^2X, -NR^1X-CO-R^2X, -SO₂-R^3X or -O-SO₂-R^3X,where R^1X is hydrogen or a 6-member heterocyclic group which is a non-aromatic saturated ring containing one or two heteroatoms selected from N and O atoms, R^2X is a 6-member heterocyclic group which is a non-aromatic saturated ring containing one or two heteroatoms selected from N or O atoms, and R^3X is C_1-6 alkyl optionally substituted with a substitute selected from group F1; or R²¹ and R²² together form a ring selected from group Z1, where group A1 consists of C_1-6 alkyl, group D1 consists of cyclopropyl and tetrahydropyranyl, group F1 consists of a halogen, group W consists of hydroxyl, C_2-7 alkoxyalkyl, phenoxy, C_2-7 alkoxycarbonyl, -NR^6XR^7X and -CO-NR^6XR^7X, where R^6X and R^7X independently denote hydrogen or C_1-6 alkyl, group V1 consists of oxo (=O) and ethylenedioxy(-O-CH₂CH₂-O-), where ethylenedioxy is allowable only if a compound of two rings with one common atom forms together with a substituted 6-member heterocyclic group, group K1 consists of a 6-member heterocyclic group which is a non-aromatic saturated ring containing one or two heteroatoms selected from N or O atoms, group U1 consists of carboxyl, C_1-6 alkoxy, phenyl and CO-NR^8XR^9X, where R^8X and R^9X denote hydrogen, and group Z1 consists of

, where R^1Z denotes C_1-6 alkyl or benzyl. The invention also pertains to a medicinal agent, a cell adhesion or cell infiltration inhibitor, as well as to therapeutic or prophylactic agents.

EFFECT: obtaining novel biologically active compounds having cell adhesion or cell infiltration inhibiting activity.

20 cl, 147 ex, 3 tbl