FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to pharmacology and concerns a circulating drug carrier. The carrier contains polyethylene glycol modified phospholipid presented by general formula
or its pharmaceutically acceptable salt: wherein X represents as follows
or
; and n represents an integer 30 to 150 wherein R1 represents a residue of saturated unbranched fatty acid having 17 to 22 carbon atoms, and 2-O-(2-diethylaminoethyl)carbamoyl-1,3-O-dioleoyl glycerol. Polyethylene glycol modified phospholipid is found in the amount of 30 wt % - 50 wt % of total weight of lipids in the carrier. What is also presented is a pharmaceutical composition containing the carrier described above and a drug.
EFFECT: group of inventions prolongs a circulation time and respectively improves the efficacy of the drug.
6 cl, 19 dwg, 5 tbl, 49 ex
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Authors
Dates
2013-02-27—Published
2008-07-30—Filed