FIELD: lipid nanoparticles.
SUBSTANCE: group of inventions relates to lipid nanoparticles for in vivo medicinal products delivery and their use. The lipid nanoparticle contains an ionizable lipid in which a 6-membered heterocyclic amine and an alkyl epoxide, a phospholipid, are linked; cholesterol, and a lipid-PEG (polyethylene glycol) conjugate in an amount of 0.5–5 mol.%.
EFFECT: lipid nanoparticles are specific for liver tissue, hepatocyte and/or LSEC (liver sinusoidal endothelial cell), have excellent biocompatibility, and can deliver a gene therapeutic agent with high efficiency.
14 cl, 10 dwg, 8 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| RECTAL MATRIX RNA DELIVERY | 2020 |
|
RU2840023C1 |
| LIPID COMPOUND AND COMPOSITION BASED THEREON | 2021 |
|
RU2825571C1 |
| IONIZABLE LIPIDS AND COMPOSITIONS THEREOF IN FORM OF NANOPARTICLES | 2020 |
|
RU2836646C1 |
| RNA PARTICLES INCLUDING POLYSARCOZINE | 2019 |
|
RU2792644C2 |
| LIPID NANOPARTICLES | 2021 |
|
RU2837542C1 |
| LIPID PARTICLES CONTAINING NUCLEIC ACIDS AND RELATED METHODS | 2010 |
|
RU2573409C2 |
| IMPROVED METHOD OF PRODUCING LIPID NANOPARTICLES LOADED WITH MRNA | 2020 |
|
RU2832672C2 |
| DISPOSABLE SYSTEM FOR STERILE OBTAINING OF LIPIDS AND NUCLEIC ACIDS PARTICLES | 2012 |
|
RU2642640C2 |
| TRIALKYL CATIONIC LIPIDS AND METHODS FOR USING THEM | 2013 |
|
RU2718053C2 |
| FUSOGENIC COMPOUNDS FOR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | 2018 |
|
RU2808990C2 |
