FIELD: medicine.
SUBSTANCE: group of inventions refers to an aqueous liposomal dispersion containing liposomes containing DOPE and at least one cationic lipid selected from a group consisting of DOTMA and DOTAP, and at least one pH regulator, wherein the aqueous composition is characterized by a pH value between 2 and 5.5, wherein said liposomes are cationic at physiological pH. Group of inventions also relates to a method of producing an aqueous liposomal dispersion; kit for preparing a pharmaceutical composition, wherein said kit contains an aqueous liposomal dispersion and, in a separate container, a pharmaceutically active nucleic acid; pharmaceutical composition for drug delivery.
EFFECT: group of inventions provides increased chemical stability of the aqueous liposomal dispersion.
24 cl, 7 dwg, 3 tbl, 9 ex
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