FIELD: biotechnology.
SUBSTANCE: invention is related particular, to a method for activating/proliferating T cells, including contacting a cell population containing T cells with a carrier for nucleic acid delivery having at least one type of T cell activating ligand added to its surface. Methods of delivering nucleic acid to T cells, comprising the step of contacting a cell population containing T cells with a nucleic acid delivery vehicle having at least one type of T cell activating ligand added to its surface, and also cell culture, composition and kit for implementing these methods, are also disclosed.
EFFECT: invention makes it possible to effectively obtain a medicinal product containing T cells.
30 cl, 6 dwg, 2 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MULTI-CHAIN CHIMERIC ANTIGEN RECEPTOR AND USES THEREOF | 2013 |
|
RU2663725C2 |
| METHODS OF EXPANSION OF ANTIGEN-SPECIFIC CAR-T-CELLS, COMPOSITIONS AND THEIR USE | 2019 |
|
RU2800920C2 |
| METHOD FOR CREATION OF T-CELLS SUITABLE FOR ALLOGENEIC TRANSPLANTATION | 2015 |
|
RU2752933C2 |
| CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATION DOMAINS | 2018 |
|
RU2800922C2 |
| MODIFIED CELLS WITH CHIMERIC ANTIGEN RECEPTOR FOR TREATING CANCER EXPRESSING CLDN6 | 2020 |
|
RU2826058C2 |
| MODIFIED MONOCYTES/MACROPHAGES EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND THEIR APPLICATIONS | 2016 |
|
RU2766690C2 |
| CANCER TREATMENT USING CHIMERIC ANTIGEN-SPECIFIC RECEPTOR BASED ON HUMANISED ANTI-EGFRvIII ANTIBODY | 2014 |
|
RU2708032C2 |
| IMPROVED METHODS FOR PRODUCING ADOPTIVE CELL THERAPY AGENTS | 2015 |
|
RU2741899C2 |
| IMMUNE CELLS DEFECTIVE BY Suv39h1 | 2018 |
|
RU2784531C2 |
| METHODS FOR PRODUCING CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR | 2015 |
|
RU2751362C2 |
