6-, 7- OR 8-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS CONTAINING THEM AND METHODS OF USING THEM Russian patent published in 2013 - IPC C07D401/04 A61K31/517 A61K31/45 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula (I) possessing an ability to inhibit cell proliferation and IL-2 production, their pharmaceutically acceptable salts, as well as to based pharmaceutical compositions. In general formula:

R¹ represents hydrogen; each of R², R³ and R⁴ independently represents: hydrogen; halogen; -(CH₂)_nOH; (C₁-C₆)alkyl optionally substituted by one or more halogens; (C₁-C₆)alkoxy; or -(CH₂)_nNHR^a, wherein R^a represents: hydrogen; -C(O)-(CH₂)_n- (6-10-member aryl) wherein aryl is optionally substituted by one or more: halogen; -SCF₃; (C₁-C₆)alkyl, said alkyl itself is optionally substituted by one or more halogens; or (C₁-C₆)alkoxy with said alkoxy itself being optionally substituted by one or more halogens; -C(O)-(C₁-C₆)alkyl; -C(O)-(CH₂)_n(C₃-C₁₀-cycloalkyl); -C(O)-(CH₂)_n-NR^bR^c, wherein each R^b and R^c independently represent: hydrogen; (C₁-C₆)alkyl; 6-10-member aryl optionally substituted by one or more: halogen; (C₁-C₆)alkyl; or (C₁-C₆)alkoxy optionally substituted by one or more halogens; -C(O)-(CH₂)_n-O-(C₁-C₆)alkyl; or -C(O)-(CH₂)_n-O-(CH₂)_n-(6-10-member aryl); or R² and R³ together can form a 6-member ring; R⁵ represents hydrogen or (C₁-C₆)alkyl; R⁶ represents hydrogen; and n represents 0 or 1; provided at least one of R², R³ and R⁴ is other than hydrogen.

EFFECT: preparing the compounds possessing an ability to inhibit cell proliferation and IL-2 production.

23 cl, 51 ex