3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND VARIANTS OF THEIR USE Russian patent published in 2023 - IPC A61K31/454 A61K31/4545 A61K31/46 A61K31/4709 A61K31/498 A61K31/506 A61K31/5355 A61K31/5377 A61K31/5415 A61K31/55 A61P35/00 A61P35/02 A61P35/04 C07D401/04 C07D401/14 C07D407/14 C07D409/14 C07D413/14 C07D417/14 C07D471/04 C07D487/04 C07D487/08 C07D495/04 C07D513/04 

Abstract RU 2795850 C2

FIELD: medicine.

SUBSTANCE: group of inventions relates to therapy, and is intended for the treatment of diseases or disorders associated with "zinc fingers 2" of the Ikaros family (IKAROS) (IKZF2). Derivatives of the compound of formula (I) are provided. In another embodiment, a pharmaceutical composition containing the said compounds is provided.

EFFECT: group of inventions provides new derivatives of the compound of formula (I), as well as a pharmaceutical composition containing these compounds with the action of an IKZF2 degrader.

13 cl, 11 dwg, 3 tbl, 74 ex

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RU 2 795 850 C2

Authors

Beckwith, Rohan Eric John

Bonazzi, Simone

Cernijenko, Artiom

Fazal, Aleem

Tichkule, Ritesh Bhanudasji

Visser, Michael Scott

Dates

2023-05-12Published

2018-08-23Filed