CRYSTALLINE HUMAN IL-12 ANTIBODIES Russian patent published in 2013 - IPC C07K16/24 C12P21/08 A61K39/395 A61P35/00 A61P37/00 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to antibody crystallisation. What is presented is a method for series crystallisation of hIL-12 specific antibody ABT-874. It enables producing an aqueous crystallisation mixture of the antibody of the concentration of approximately 0.5 to approximately 280 mcg/ml and polyalkylene glycol of average molecular weight approximately 400-10000 and of the concentration of 5% to 30% (wt/vol.). The prepared mixture is incubated at pH approximately 4 to approximately 6.5 and at temperature approximately 4 °C to 37 °C for form the crystals 2-500 mcm long. There are described versions of the hIL-12 crystals prepared by said method. There are disclosed versions of the pharmaceutical composition, an injected liquid composition, a crystalline suspension composition, versions of a method of treating the hIL-12 mediated disorders, based on using the antibody crystals. What is presented is using the crystals for preparing the pharmaceutical composition for treating IL-12 associated disorder.

EFFECT: using the invention enables producing the antibody crystals on a commercial scale that can find application for industrial production of the antibody crystals for treating the hIL-12 mediated disorders.

40 cl, 13 dwg, 3 tbl, 47 ex